Long-term outcomes, on the other hand, represent the results of repeated instances of exposure to food cues accompanied by heightened food cue reactivity and behavioral outcomes over prolonged periods, which can lead to the strengthening of the effectiveness of food cues on eliciting overeating through learning processes, including incentive sensitization [74,75], Pavlovian conditioning (i.e., a direct association between food cues and food intake), and operant conditioning (i.e., a reinforcement of food-seeking behaviors due to the rewarding nature of palatable foods) [40]
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In clinical trials, participants who started at 2mg and escalated every 4 weeks through 4mg, 8mg, and finally 12mg experienced a gradual onset of appetite suppression
What to do: If you experience any of these symptoms, call your healthcare provider immediately
Melanocortin Signaling Research