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It has been suggested by the European Journal of Pharmacology that Nicotine may decrease the development of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and the bone resorption activity of osteoclast-like cells. [43] These two findings highlight the notion that nicotine has a positive effect on the differentiation and mineralization of osteoblastic cells, while it negatively affects the activation and differentiation of osteoblastic cells

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