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Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)

however, after the appearance of prospective randomized studies that indicated an increase in the incidence of breast cancer, the establishment of this therapy has been adjusted to the presence of certain risk factors, symptoms, and the evolution of patients (Zhao and Brinton, 2006)

The article says combining them increases the risk of gastrointestinal side effects, nausea, and hypoglycemia, with the hypoglycemia concern sharpest when insulin or sulfonylureas are also in the regimen

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Doses shown on the platform include 1mg, 2mg, and 2.5mg (availability varies by prescription and provider)