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Unpublished results from the first phase II trial with the triple combination of semaglutide, cilofexor and/or firsocostat treatment for 24 weeks in 108 patients with NASH showed significant improvements in hepatic steatosis (measured with MRI) and liver injury (measured by serum alanine aminotransferase) in the combination treatment arm vs semaglutide monotherapy (56)

In particular, inhibitors or activators targeting cellular components, as well as biomolecules, enzymes, and nutrients, can stimulate apoptotic signaling pathways

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