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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from licensed agents such as semaglutide or tirzepatide

Check B12 levels at baseline and every 6 months

Patients should seek medical attention for persistent right upper quadrant or epigastric pain, fever, or jaundice

This means that rare adverse effects occurring outside controlled trial settings would not be systematically documented

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