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Tesofensine produced weight loss significantly greater than placebo and was more effective than any currently approved obesity drug at the time. Astrup et al., The Lancet Additional Findings: The majority of weight loss came from visceral fat and abdominal adiposity Lean body mass was preserved , unlike with most appetite suppressants Participants reported reduced hunger and better diet adherence Tesofensine significantly improved waist circumference , lipid profiles, and fasting glucose These findings have led to continued interest in Tesofensines use for body recomposition not just for general weight loss, but for fat-specific reduction without muscle sacrifice

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Groundbreaking clinical trials published in late 2023 and 2024 show that semaglutide, approved in 2019 for treating diabetes and in 2021 for weight management, also reduces rates of heart disease and kidney disease, and reduces tissue and systemic inflammation