Many people, several months into GLP-1 treatment, find themselves experiencing symptoms related to depression, anxiety, or stress that they had been eating around for years
GLP-1 agonists were originally approved to treat Type 2 Diabetes (T2D) but their most recent incarnations, which consist of both next generation GLP-1s and combinations (Ozempic, Mounjaro, Wegovy, Zepbound), have moved beyond the realm of T2D into the treatment of obesity
The mechanism is disputed, but several theories have been proposed: (a) that hemoglobin or hemoglobin products are directly toxic to proximal tubule cells, (b) that precipitation of hemoglobin results in tubular obstruction and renal failure, and (c) that direct renal injury by hemoglobin does not occur but instead products of intravascular hemolysis result in hypotension and other systemic and local vascular events, and these lead to renal failure ( 135 , 136 , 137 , 138 )
Specific Populations Pediatric Patients The pharmacokinetics and pharmacodynamics (glucosuria) of dapagliflozin in pediatric patients aged 10 to 17 years with type 2 diabetes mellitus were similar to those observed in adult patients with same renal function
Why Chicken Works Well for High-Protein GLP-1 Meals Grilled chicken skewers are more than a convenient meal prep option
