BV-2 cells were exposed for 15 min to various concentrations (2, 20, 50 mol/L) of the nonselective COX inhibitor indomethacin prior to treatment with p-aminophenol or AM404 [Figures 8 and 9]
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Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid
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Notably, the peptide is believed to possess a greater affinity for MC1R over -MSH, suggesting that it might increase melanin production, thereby promoting skin pigmentation even in the absence of sunlight exposure