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J Biol Chem 1987
In contrast, pre-treatment with antioxidants in the Mel+CARB and GSH+CARB groups markedly reduced the severity of tissue damage
In this specific cycle: 1 Hydrogen peroxide, a free radical and reactive oxygen species, is converted into water (harmless), and oxygen 2 Two molecules of reduced Glutathione [GSH (the active antioxidant form of glutathione)] are used by the Glutathione peroxidase enzyme to neutralize one molecule of hydrogen peroxide 3 NADPH is used by glutathione reductase enzyme to reduce ("recycle") glutathione disulfide back into usable reduced glutathione Key players: Selenium: Essential for the enzyme that initiates the breakdown of hydrogen peroxide Riboflavin (FAD - coenzyme form of riboflavin): essential for the enzyme that restores the oxidized Glutathione back to its more useful state.
Dong, L., Li, B., Verkhratsky, A
These body composition changes occurred without any measured change in food intake meaning the weight loss was driven by metabolic changes rather than appetite suppression
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