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119 Research indicates that factors such as age, diet, alcohol consumption, fructose-rich intake, pharmacologic interventions and diseases, such as obesity, insulin resistance, Down syndrome, and kidney disease, contribute to the development of hyperuricemia 120,121,122,123,124 (Fig

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Despite decades of research, no cure exists, and current treatments focus primarily on symptom management rather than altering the disease trajectory (Sun and Zhang, 2024)

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