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Moreover, DN exhibits significant clinical heterogeneity (e.g., type 1 vs

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Overall, our binding analysis and Th-T assays of Syn 1103 with various interactors tested suggest that random cellular proteins are sequestered within inclusions due to the promiscuous binding nature of Syn 1103 , rather than exerting any inhibitory effect on its aggregation

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In doing so, patients find that their appetite significantly decreases, they consume less food, and they lose weight without feeling hungry