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"We've got the four pillars we rely on, and if you think of them as legs of a chair, every time you take one of them away, things don't work as well," Basilico explained

Before we dig into the data, lets look at the biological plausibility here

While there are varying perspectives on this issue, in a viewpoint that I was pleased to co-author with Sam Klein and Kevin Hall just published in JAMA, we suggest that the concern regarding physical frailty or sarcopenia with GLP-1-based medications may not be as grounded as some argue

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Facial flushing results from melanocortin-mediated nitric oxide release causing peripheral vasodilation the same mechanism that produces erections as a side effect of Melanotan-2