Peptides work cumulatively
Experimental work indicates that statins disturb mitochondrial complexes, although this sits mainly in mechanistic studies rather than patient-level trial In clinic I treat these hypotheses as prompts to focus on whole-mitochondrial support sleep, nutrient-dense diet, physical activity matched to capacity, and careful review of polypharmacy rather than chasing every possible supplement
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The original diagnosis may have been incomplete, the pain may be atypical, vascular compression may persist, or the main problem may now be nerve injury, facial numbness, anesthesia dolorosa, postherpetic pain, peripheral branch irritation, or central sensitization
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