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IV therapy is generally considered safe for appropriate candidates when administered by licensed clinicians under physician supervised protocols

Reversibility of symptomatic peripheral neuropathy with bortezomib in the phase III APEX trial in relapsed multiple myeloma: impact of a dose-modification guideline

However, this approach must be considered as an add-on rather than an alternative to the search for novel drugs

Administering an excessively high KLOW dosage can lead to off-target effects, toxicity, or even mask the desired physiological response, making data interpretation impossible