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Furthermore, administration of acamprosate led to increased GABA binding in the hippocampus and thalamus, suggesting that acamprosate might influence GABAA transmission by presynaptic inhibition of GABAB receptors (180)

Results showed a significant reduction in 5-HT levels in the TMAO + MPTP group compared to the MPTP group, indicating that TMAO diminishes neurotransmitter 5-HT levels, influencing the onset of PD