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Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP

2009 Sep;21(2):77-91

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Such an effect results from different mechanisms, including the activation of muscarinic cholinergic receptors, and the increased expression of mGlu2 receptors in dorsal root ganglia neurons, by means of an acetylation mechanism involving transcription factors of the nuclear factor (NF)-kappaB family