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The List also includes S0: Non-Approved Substances, which covers substances without current approval by a governmental regulatory health authority for human useful use

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Documentation Burden: To be legal, the prescriber must document why the combination product is medically necessary for that specific patient (e.g., severe non-compliance with multiple distinct administrations)

Judk P, Esposito S, Coppieters G, Van Eenoo P, Deventer K