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These cells are sensitive to inflammation and oxidative stress, especially with aging or poor diet

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SP remodels bone homeostasis in vitro via NRF2/KEAP1 signaling pathways NRF2 is a redox-sensitive transcription factor that codes for versatile cytoprotective proteins, including antioxidant, detoxification, and anti-inflammatory proteins 26

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Neurology 96 , e2098e2108 (2021)