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When the C-terminal Thr1273 is mutated to Glu1273, this alters the charge balance, likely resulting in weakened interactions between the N- and C-terminal halves of the S tail

Two kidney outcomes were examined: new onset macroalbuminuria and a composite renal outcome (including a combination of development of new-onset macroalbuminuria, decline in estimated glomerular filtration rate (eGFR), progression to end-stage kidney disease, or death attributable to kidney causes, as reported in each study)

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