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Peptides often have a more targeted mechanism than steroids, which may reduce systemic side effects

DOI: 10.1016/j.freeradbiomed.2019.02.009

Corticosteroids promote: Fat redistribution , causing central (truncal) obesity and the characteristic "cushingoid" appearance with prolonged use Fluid retention , leading to weight gain that may not reflect true fat accumulation but can be discouraging Muscle protein breakdown , reducing lean body mass and potentially lowering metabolic rate Insulin resistance , making weight loss more difficult The magnitude of these effects is generally dose- and duration-dependent

We acknowledged this as a limitation of the study and are aware that it may affect the interpretation of the results

Grawert wasnt involved in the study