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This restores programmed cell death in cancer cell lines including SH-SY5Y neuroblastoma and U937 histiocytic lymphoma at 1-10 nanomolar concentrations, while paradoxically stimulating healthy NIH-3T3 fibroblast growth
The appetite effect is a matter of neural signaling: area postrema neurons project to the parabrachial nucleus and onward to forebrain regions that govern the decision to stop eating, and this circuit also engages hedonic pathways that reduce the rewarding value of food
The peptide normalized enzyme markers of muscle damage including creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase, indicating restoration of muscle cell membrane integrity and metabolic function
Zhang, X
16701681, Nov
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