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Clinical trials (e.g., SCALE) show that highdose liraglutide can produce significant weight loss and improvements in prediabetes, lipids, and blood pressure when combined with a reducedcalorie diet and increased activity

SELECT trial: GLP-1 RAs in non-diabetic patients The SELECT trial represented a paradigm shift by evaluating semaglutide exclusively in patients without diabetes

Semaglutide works by activating the GLP-1 receptor , which plays a key role in controlling blood glucose and reducing appetite

Sun exposure, smoking, and stress can reverse the effects

Even if CK levels are initially normal, continue to follow them, as rhabdomyolysis may emerge over time