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Furthermore, in vivo models suggest that intratesticular or peritesticular injections of PRP may promote spermatogenesis, restore testicular architecture, and mitigate damage caused by toxins, ischemiareperfusion injury, or diabetes-induced degeneration [35,36,37,38]

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During CRPC development, the tumor undergoes several adaptions counteracting supraphysiological androgen levels, including increased androgen synthesis, AR amplification, AR mutation, AR alternative splicing, MYC overexpression, and hyperactive STAT signaling [113,178,183,184]