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Furthermore, some cancer cells can develop resistance to oxidative stress, making antioxidant therapy less effective

Independently from these controversies, coffee has been described as probably the most relevant source of dietary antioxidant compounds [5], which are thought to counteract the action of reactive oxygen species (ROS), the main contributors to the development of oxidative stress

This may be due to additional antioxidant enzymes like CAT and SOD are present, which are so powerful and sensitive to H 2 O 2 -induced oxidative stress that GSH-Px did not respond significantly to it

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