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Serious risks can include pancreatitis, gallbladder disease, and kidney injury, and these medications carry a boxed warning for the risk of thyroid C-cell tumors

Understanding the established side effect profile of tirzepatide and the nature of allodynia helps patients and clinicians distinguish medication-related symptoms from other causes

Semaglutide GLP-1 works as a GLP-1 receptor agonist to regulate appetite and blood sugar, while tirzepatide combines GIP and GLP-1 receptor agonist actions for enhanced weight loss benefits