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Studies using cytokine-deficient (knockout) mice

1 Introduction Migraine manifests as a chronic neurovascular disease characterized by unilateral or bilateral throbbing severe headaches, predominantly unilateral, recurring with symptoms such as nausea, vomiting, photophobia, and phonophobia that impair autonomic nervous system functions (Vos et al., 2020)

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In our study exercise induced an increase in cellular oxidative stress (as shown by the increase in LPO content) and NO levels, and these factors could account for the increase in oxidative stress