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It meets all the classic criteria: How Vitamin D Functions Like a Hormone: Made in the body your skin synthesizes vitamin D3 when exposed to UVB sunlight Travels through the bloodstream carried by vitamin Dbinding protein (DBP) Converted into an active form calcitriol is produced primarily in the kidneys Acts on distant tissues including bones, intestines, and immune cells Regulated by feedback when calcium is high, less calcitriol is produced These features make calcitriol a true endocrine hormone, similar to cortisol or estrogen

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A targetable lifr-nf-Kb-lcn2 axis controls liver tumorigenesis and vulnerability to ferroptosis

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