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So the guy starts going to the bathroom and says, "Hey, I'm a huge fan, also went to Vanderbilt..." Jay throws his head back, eyes half-closed because he's drunk, interrupts him with, 'DOOOONNNNTTTTTT CAAAAAARRRREEEEEE.'" (Story via Kissing Suzy Kolber) We can only imagine Jay's response to the endless jokes at his expense:

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They are self-limiting the body metabolises nicotine efficiently and the effects pass

But that doesnt mean its ruined