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Food Diary: Keep a diary or use a mobile app to record your food intake, including portion sizes and calories

Leptin resistance where the hypothalamus no longer responds appropriately to adipokine signals is a hallmark of established obesity, as described in StatPearls (NCBI)

Once the medication is prescribed, your physician will instruct you on how much medication to administer weekly

As we would expect, the semaglutide group lost a significant amount of body weight, approximately 10% of body weight at 104 weeks post randomization compared to less than 1% in the placebo group

How quickly does semaglutide GLP-1 affect appetite