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doi: 10.1001/jamadermatol.2021.3492
Following publication of the REDUCE IT study results, in which the use of EPA (icosapent ethyl 2 2 g/day) for 4.9 years in patients optimally treated with statins with fasting TG concentration 1.5 to 5.6 mmol/l (135499 mg/dl) and high cardiovascular risk resulted in a reduction of incidence of cardiovascular events by 25% [147], European experts recommended adding EPA to a statin in such cases (IIaB) [9]
Therefore, butyrate might be a particularly interesting therapeutic target
This side effect may cause symptoms such as weakness, fatigue, muscle cramps, or irregular heartbeat
Oral administration follows a ramping protocol: 250 micrograms daily for the first three weeks, increasing to 500 micrograms for maintenance
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