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Insufficient esterification of free cholesterol promotes ER stress and the recruitment of the E3 ligase RNF5, thereby activating CD36 ubiquitination in ACAT2-deficient intestinal cells

Monitor the initiation and guide the patient through titrating from lowest dose to the target dose of medication

Supplementary Table 1) was mixed with 3 l of transfection reagent (DharmaFECT 1, Horizon Discovery) in a total volume of 500 l of OptiMEM (Gibco) and incubated for 20 minutes at room temperature

Calculations were made on the amounts of various elements using atomic absorption spectrometry

However, any new or worsening symptoms should be discussed with a healthcare provider