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Joshua Stewart, MD, a reproductive endocrinologist at Weill Cornell Medicine

Also, Novo Nordisk, the manufacturer of FDA-approved semaglutide products, has reported cases of impurities found in compounded semaglutidewith one specific product tested found to have over 24% impurities

Ecnoglutide vs Semaglutide: Biased GLP-1 Agonist vs Proven Standard of Care Evidence-based comparison of ecnoglutide (cAMP-biased GLP-1 agonist) and semaglutide (selective GLP-1 agonist), including SLIMMER Phase 3, STEP, and SELECT trial data

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In a trial of 1,961 adults conducted over 68 weeks, only 4.5% of those taking semaglutide discontinued the medications due to side effects, so both medications are safe for use, including in the long term