Glossary ARS Autonomously replicating sequence ATCC American Type Culture Collection COSMIC Catalogue Of Somatic Mutations In Cancer CRIMEtoYHU Choosing the Right Cancer-Associated Mutation for Evaluation to Yeast HUmanization CRISPR Clustered regularly interspaced short palindromic repeats CRISPR-AID Trifunctional CRISPR system comprising CRISPRa, CRISPRi, and CRISPRd CRISPRi CRISPR interference CYGD Comprehensive Yeast Genome Database DAmP Decreased abundance by mRNA perturbation DDCR DNA damage checkpoint repair dSLAM Diploid-based synthetic lethality analysis on microarray HIPHOP Haploinsufficiency profilinghomozygous profiling MAGESTIC Multiplexed accurate genome editing with short, trackable, integrated cellular barcodes MAGIC Multifunctional genome-wide CRISPR MAVE Multiplexed assays of variant effect MoBY-ORF Molecular-barcoded yeast ORF MSP Multicopy suppression profiling NGS Next-Generation Sequencing NHEJ Nonhomologous end joining PAMs Protospacer adjacent motifs PPIs Proteinprotein interactions SGA Synthetic genetic array SGD Saccharomyces Genome Database SNP Single-nucleotide polymorphisms STRING Search Tool for the Retrieval of Interacting Genes TAP Tandem affinity purification TEV Tobacco etch virus Tn Transposon ts Temperature sensitive UMI Unique molecular identifier uORFs Upstream open reading frames Y2H Yeast two-hybrid YAGM Yeast-Associated Genes Miner YKO Yeast knockout YPD Yeast Protein Database Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
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Most claims center on alleged severe symptoms that go beyond expected tolerance issues, such as persistent vomiting, dehydration, inability to keep food down, or complications requiring ER care and other medical attention
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