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Yes, studies suggest it is safe for long-term use, but ongoing monitoring is recommended

BMJ 324:15125, PMID: 12077044 Passeri M, Cucinotta D, Abate G, Senin U, Ventura A, Stramba BM, Diana R, La Greca P, Le Grazie C (1993) Oral 5-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study

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