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Participants received tirzepatide (Mounjaro/Zepbound) at escalating doses up to 15 mg weekly for 52 weeks

However, there is one major difference that separates retatrutide from tirzepatide: retatrutide targets three hormone receptors, while tirzepatide targets two

When used in combination with lifestyle modifications, GLP-1 agonists can result in significant reductions in body weight, along with improvements in related conditions such as high blood pressure, high cholesterol, and type 2 diabetes

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