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By promoting the undocking of secretory granules (SG), GLP-1(936) reduces the number of granules available for exocytosis, thereby decreasing the release of glucagon

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Our results are consistent with previously reported changes in targeted-metabolite levels (butyrates, carnitines, BCAAs, citrate, uridine, and urate) 2,16,20,27 , which in turn, validate the protocol used here

Sanyal A, Charles ED, Neuschwander-Tetri BA et al (2019) Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial