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Two additional studies demonstrate a positive relationship between total testosterone levels and insulin sensitivity in normal [7] and diabetic men [8]

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Beyond their islet effects, incretins exert pleiotropic actions on the brain (appetite and satiety regulation), gastrointestinal tract (delayed gastric emptying), adipose tissue (lipolysis modulation), and liver (inhibition of hepatic glucose output) (13)

Our previous study has revealed that the gene expression of mitochondrial biogenesis markers ( PGC1 , NRF1 , and TFAM ) and mtDNA-encoded OXPHOS genes are all downregulated in the skeletal muscle of SLD chickens and GHR knockdown cells ( GHR knockdown cells, indicating that GHR exhibits a positive effect on mitochondrial biogenesis