Inhibition of cholesterol esterification in T cells by genetic ablation or pharmacological inhibition of ACAT1 (a key cholesterol esterase) can lead to potentiated effector function and enhanced proliferation of CD8(+) T cells by increasing plasma membrane cholesterol levels, which causes enhanced T-cell receptor clustering and signaling as well as more efficient formation of the immunological synapse, thereby controlling the growth and metastasis of mouse melanoma (284)
Assessment of antioxidant enzyme activities and oxidative stress markers To assess antioxidant enzyme activities and oxidative stress markers, frozen-thawed spermatozoa of each group (repeated in triplicated) were collected and centrifuged at 800g for 20 min to separate spermatozoa from seminal plasma
Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma
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