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The most compelling studies of efficacy have been done in cell cultures and small animals

The precise molecular mechanism has not been characterized in human tissue

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Furthermore, elevated uric acid observed in SCC47 compared to Detroit562 indicates active purine catabolism, suggesting differences in proliferation rates or preferential recycling of purines back to guanosine monophosphate (GMP) and inosine monophosphate (IMP) 32

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