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Pregnant, planning pregnancy, or breastfeeding

The relevance of this detoxification pathway extends significantly to the vulnerable preterm infant population

The most commonly reported adverse effects include: Nausea and vomiting Diarrhoea or constipation Abdominal pain or discomfort Decreased appetite Dyspepsia (indigestion) Headache Dizziness Gastro-oesophageal reflux Fatigue (particularly noted in weight management trials) These gastrointestinal symptoms typically occur during dose escalation and often diminish over time as the body adjusts to treatment

This connection existed in both children and adults

These symptoms are generally most pronounced when treatment is initiated and tend to decrease in intensity with continued use of the medication