Activation of serotonin receptor 7 (5-HT 7 R) using its agonist LP-211 showed beneficial effects on anxiety-like behaviors, social and cognitive deficits, in the VPA model [62]
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This antioxidative effect was attributed to the restoration of GSH levels, upregulation of antioxidant enzymes, and suppression of thioredoxin interacting protein, a key mediator of oxidative stress and cytotoxicity (Lim et al., 2024)
At the same time, it appears not to alter FSH, LH, prolactin, or TSH across evaluations of cell cultures in laboratory settings, with only minimal actions on ACTH and cortisol
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