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GLP-1 medications slow gastric emptying and alter appetite signaling, which can indirectly affect bile flow and lipid metabolism

That said, real-world results can sometimes differ due to factors such as inconsistent dose adjustments or challenges with staying on the treatment plan

These findings are very robust and compelling, says Jorge Moreno, MD, assistant professor and obesity medicine doctor at Yale Medicine in New Haven, Connecticut, who was not involved in the study

Differential Side Effects: The Glucagon Variable The unique addition of the glucagon receptor agonism in Retatrutide introduces one primary differential side effect that must be carefully managed: heart rate increases

Postmarketing studies assessing its longer-term safety will also provide further guidance on treatment duration