type 1 diabetes glp-1 receptor agonists are increasingly used to treat 2 and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal SGLT2i and GLP-1 RA therapy

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Duriez, P., Ramoz, N., Gorwood, P., Viltart, O

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Nitric oxide-dependent biodegradation of phenanthrene and fluoranthene: the co-occurrence of anaerobic and intra-aerobic pathways

This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice