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The complex interplay among lipid peroxidation, chronic inflammation, and metabolic reprogramming reveals multiple targetable pathways for therapeutic exploitation

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26,43,44 The enzymes UGT (glucouronidation), SULT, CYP 450, GST, N -deacetylase (deacetylation), NAT2 (deacetylation), and fatty acid amide hydrolase are involved in APAP metabolism and have been shown to be related to both hepatic and nephrotoxic effects of the analgesic medication

Dynamic light scattering (DLS) measurements demonstrated that NP4 had an average hydrodynamic diameter of 126 nm and a PDI of 0.16 (Fig