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Clinical trials and post-marketing surveillance have identified an increased risk of cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation) in patients taking these medications

[11] Clinical studies such as the SUSTAIN programme (semaglutide) and AWARD trials (dulaglutide) demonstrate that GLP-1 receptor agonists can reduce HbA1c by approximately 0.81.5% on average, with some patients achieving greater reductions depending on baseline values and adherence

A study published in JAMA, for example, found participants who took semaglutide had a 16 percent weight change compared to liraglutide participants who saw a 6.4 percent difference

Retatrutide is the first medication to mimic three hormones, GLP-1, GIP and glucagon, rather than the one or two that current medications use

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