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doi: 10.3390/ijms232314631 59 FinanBMaTOttawayNMllerTDHabeggerKMHeppnerKMet al

The tradeoff is regulatory: compounded drugs are not FDA-approved 1 and should be discussed carefully with a provider

That said, patients with active diabetes or significant metabolic dysfunction should have any investigational peptide protocol reviewed by their endocrinologist or primary care physician alongside their supervising aesthetic medicine provider

Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]

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