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Jaworski FM, Gentilini LD, Gueron G, Meiss RP, Ortiz EG, Berguer PM, et al

The impairment or absence of GLP-1 effects in type 2 diabetes suggests a role in its pathogenesis

Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

Invest Ophthalmol Vis Sci 46: 3913-3921

Studies demonstrate the peptide participates in transcriptional regulatory mechanisms common to both the pineal gland and retinatissues sharing common embryonic origin and similar peptide responsiveness