References Banday MZ, Sameer AS, Nissar S
Vitamin B12 is key for the bodys nerve function and blood cell production
Moreover, endothelial cell inflammation results in the proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), thereby fostering intimal thickening and vascular remodeling and accelerating the deposition of atherosclerotic plaques [6]
As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]

Very common side effects (affecting more than 1 in 10 people) include: Nausea, vomiting, and diarrhoea (usually temporary) Reduced appetite Common side effects (affecting up to 1 in 10 people) include: Constipation Abdominal pain or discomfort Headache Injection site reactions Fatigue Contact your GP promptly if you experience: Persistent or severe abdominal pain , particularly if radiating to the backthis may indicate pancreatitis Persistent vomiting that prevents adequate fluid intake Signs of dehydration : reduced urination, dizziness, dry mouth Symptoms of hypoglycaemia (if taking alongside insulin or sulphonylureas): trembling, sweating, confusion, rapid heartbeat Visual changes or eye pain, especially if you have diabetic retinopathy Unexplained weight loss exceeding expected therapeutic effect Mood changes or thoughts of self-harm Right upper abdominal pain, yellowing of skin/eyes, or dark urine which may indicate gallbladder problems Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, persistent abdominal pain with vomiting Signs of severe allergic reaction: difficulty breathing, facial swelling, severe rash Symptoms of diabetic ketoacidosis (particularly if insulin doses have been reduced): excessive thirst, frequent urination, confusion, fruity breath odour Severe hypoglycaemia with loss of consciousness Important safety information: GLP-1 medications are not recommended during pregnancy or breastfeeding
