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Management: adjusting dose/frequency, topical treatments, or in some cases a dermatologist referral

In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

Neuro Oncol

The thyroid gland contains high concentrations of selenium-dependent enzymes , including glutathione peroxidases and deiodinases, which are involved in antioxidant protection and thyroid hormone metabolism

J., Przyrembel, H., Schlotzer, E., and Sauer, P