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The Foundation of Modern Weight Management: GLP-1 and GIP/GLP-1 Agonists The landscape of weight management has been significantly reshaped by a class of medications known as incretin mimetics, primarily glucagon-like peptide-1 (GLP-1) receptor agonists and, more recently, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists

Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]

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